The Anthologist in business development One St Peter’s Square will be a 6,000 sq ft, 185-cover restaurant.
It will showcase the group’s signature features – a large statement bar, a mix of traditional dining and lounge seating, banquettes and booths.
The all-day drinking and dining destination will trade seven days a week for breakfast, brunch, lunch, afternoon tea and dinner.
Jillian MacLean, managing director of Drake & Morgan, said: “I’m delighted to be launching our second site in Manchester on the back of The Refinery in Spinningfields.
“Manchester is a modern and vibrant city that Drake & Morgan loves being a part of, and we are confident that The Anthologist will provide the city with a refreshingly independent bar that comes with a few new exciting additions for our lovely customers.”