It follows the appointment of his long-term prodigy Nathaniel Tofan as head chef at the venue earlier this year.
“I feel the time is right for Nat to get the recognition he deserves at Manchester House,” said Byrne.
“He has been running the show for a long time since I widened my role within Living Ventures and been by my side since the day we opened, so is more than ready to put his own mark on the menu.
“I can’t wait to see what he comes up with! I’ve had a great time at Manchester House and am very proud of what we’ve achieved. I know that the business is in safe hands.”
Jeremy Roberts CEO of Living Ventures added: “We’re sorry to see Aiden leaving us and I want to take this opportunity to thank him publicly for his enormous contribution in establishing Manchester House on the culinary landscape of the city.
“We wish him every success for the future. Living Ventures have a history of developing young talented people within the company and we’re excited to see Nat achieve his potential.”
Byrne is leaving in January to take the reins at D&D London’s upcoming 20 Stories restaurant at Manchester’s 1 Spinningfields development. The 300-cover site, which will feature an outdoor terrace, is set to open early next year.
PICTURE (from left): Aiden Byrne, Jeremy Roberts and Nathaniel Tofan