The contracts with brand owner Whitbread are for schemes in Ulverston in the Lake District, Rhyl in north Wales and Bridlington on the east Yorkshire coast.
The 79-bedroom Premier Inn and adjoining Thyme Restaurant next to the Ulverston Canal are due to be completed in December.
Medlock is scheduled to finish a 70-bedroom hotel and Brewers Fayre restaurant at the Rhyl waterfront development project in January.
The Bridlington scheme, which involves the construction of an 82-bedroom Premier Inn and Brewers Fayre next to a new seafront leisure centre, is also due to be completed in January. The hotel is the first to be built in the resort since 1937.
Medlock project director Dan Lewis said: “We are delighted to further cement our relationship with Whitbread with the award of these contracts.
“The target for further hotels in the UK is well-documented and presents a tremendous opportunity for Medlock to be part of this expansion.
“We have a strong track record in the successful delivery of previous projects and look forward to achieving outstanding standards of work again to help the Premier Inn brand maintain its position as the country’s most popular hotel brand.”
PICTURE: A computer-generated image of the new Premier Inn at Bridlington